FGF21 polypeptides comprising two or more mutations
AssigneeAmgen Inc.
InventorsEdward John Belouski, Murielle Marie Ellison, Agnes Eva Hamburger, Randy Ira Hecht, Yue-Sheng Li, Mark Leo Michaels, Jeonghoon Sun, Jing Xu
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Abstract
The invention provides nucleic acid molecules encoding FGF21 mutant polypeptides, FGF21 mutant polypeptides, pharmaceutical compositions comprising FGF21 mutant polypeptides, and methods for treating metabolic disorders using such nucleic acids, polypeptides, or pharmaceutical compositions.
Claims15
An isolated polypeptide comprising the amino acid sequence of SEQ ID NO:4, wherein the polypeptide comprises (a) an arginine residue at position 98 of SEQ ID NO:4;
- and (b) a glycine residue at position 171 of SEQ ID NO:4.
A fusion polypeptide encoded by nucleotides 1-1272 of SEQ ID NO:37.
Dependencies are inferred from the claim text.