Combinations and modes of administration of therapeutic agents and combination therapy
AssigneeAbraxis BioScience, LLC
InventorsNeil P. Desai, Patrick Soon-Shiong
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Abstract
The present invention provides combination therapy methods of treating proliferative diseases (such as cancer) comprising a first therapy comprising administering to an individual an effective amount of a taxane in a nanoparticle composition, and a second therapy which may include, for example, radiation, surgery, administration of chemotherapeutic agents, or combinations thereof. Also provided are methods of administering to an individual a drug taxane in a nanoparticle composition based on a metronomic dosing regime.
Claims34
A method of treating non-small cell lung cancer (NSCLC) in a human individual comprising administering to the individual:
- a) an effective amount of a composition comprising nanoparticles comprising paclitaxel coated with albumin, and
- b) an effective amount of a platinum-based agent, wherein the platinum-based agent is cisplatin or carboplatin, and wherein the nanoparticle composition is free of cremophor.
Dependencies are inferred from the claim text.