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US 8,034,351 B2Granted
Mucin fusion polypeptide vaccines, compositions and methods of use thereof
AssigneeRecopharma AB
InventorJan Holgersson
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Abstract
The present invention provides compositions and methods for augmenting vaccine immunogenicity using mucin-immunoglobulin fusion proteins.
Claims7
A purified composition comprising:
- a dimerized fusion polypeptide comprising a first polypeptide linked to a second polypeptide, wherein the first polypeptide is a mucin polypeptide and is glycosylated by a α1,3 galactosyltransferase and the second polypeptide comprises at least a region of an immunoglobulin polypeptide covalently linked to a third polypeptide, wherein the third polypeptide is a viral polypeptide, a bacterial polypeptide or a parasitic polypeptide.
Dependencies are inferred from the claim text.