Antigen binding proteins to proprotein convertase subtilisin kexin type 9 (PCSK9)
AssigneeAmgen Inc.
InventorsSimon Mark Jackson, Bei Shan, Wenyan Shen, Chadwick Terence King
Life of this patent
Estimating the term…
Abstract
Antigen binding proteins that interact with Proprotein Convertase Subtilisin Kexin Type 9 (PCSK9) are described. Methods of treating hypercholesterolemia and other disorders by administering a pharmaceutically effective amount of an antigen binding protein to PCSK9 are described. Methods of detecting the amount of PCSK9 in a sample using an antigen binding protein to PCSK9 are described.
Claims27
An isolated neutralizing antigen binding protein that binds to a PCSK9 protein comprising the amino acid sequence of SEQ ID NO:
- 1, wherein the neutralizing antigen binding protein comprises:
- a heavy chain polypeptide comprising the following complementarity determining regions (CDRs):
- a heavy chain CDR1 that is a CDR1 in SEQ ID NO:
- 49;
- a heavy chain CDR2 that is a CDR2 in SEQ ID NO:
- 49;
- a heavy chain CDR3 that is a CDR3 in SEQ ID NO:
- 49 and a light chain polypeptide comprising the following CDRs:
- a light chain CDR1 that is a CDR1 in SEQ ID NO:
- 23;
- a light chain CDR2 that a CDR2 in SEQ ID NO:
- 23;
- and a light chain CDR3 that is a CDR3 in SEQ ID NO:
- 23.
An isolated neutralizing human monoclonal antibody that binds to a PCSK9 protein comprising:
- a heavy chain polypeptide comprising the following complementarity determining regions (CDRs):
- a heavy chain CDR1 that is a CDR1 in SEQ ID NO:
- 49;
- a heavy chain CDR2 that is a CDR2 in SEQ ID NO:
- 49;
- a heavy chain CDR3 that is a CDR3 in SEQ ID NO:
- 49;
- and
- a light chain polypeptide comprising the following CDRs:
- a light chain CDR1 that is a CDR1 in SEQ ID NO:
- 23;
- a light chain CDR2 that a CDR2 in SEQ ID NO:
- 23;
- and a light chain CDR3 that is a CDR3 in SEQ ID NO:
- 23,
- wherein each CDR is defined in accordance with the CDR definition of Kabat.
An isolated neutralizing human monoclonal antibody that binds to a PCSK9 protein comprising:
- a heavy chain polypeptide comprising:
- the amino acid sequence of SEQ ID NO:
- 180;
- the amino acid sequence of SEQ ID NO:
- 175;
- and
- the amino acid sequence of SEQ ID NO:
- 308;
- and
- a light chain polypeptide comprising:
- the amino acid sequence of SEQ ID NO:
- 395;
- the amino acid sequence of SEQ ID NO:
- 162;
- and
- the amino acid sequence of SEQ ID NO:
- 158.
An isolated neutralizing human monoclonal antibody that binds to a PCSK9 protein comprising:
- a heavy chain polypeptide comprising the following complementarity determining regions (CDRs):
- a heavy chain CDR1 that is a CDR1 in SEQ ID NO:
- 308 or a CDR1 in SEQ ID NO:368;
- a heavy chain CDR2 that is a CDR2 in SEQ ID NO:
- 175;
- a heavy chain CDR3 that is a CDR3 in SEQ ID NO:
- 180;
- and
- a light chain polypeptide comprising the following CDRs:
- a light chain CDR1 that is a CDR1 in SEQ ID NO:
- 158;
- a light chain CDR2 that is a CDR2 in SEQ ID NO:
- 162;
- and a light chain CDR3 that is a CDR3 in SEQ ID NO:
- 395.
An isolated neutralizing human monoclonal antibody that binds to a PCSK9 protein comprising:
- a heavy chain polypeptide comprising the following complementarity determining regions (CDRs):
- a heavy chain CDR1 that is a CDR1in SEQ ID NO:
- 49;
- a heavy chain CDR2 that is a CDR2 in SEQ ID NO:
- 49;
- a heavy chain CDR3 that is a CDR3 in SEQ ID NO:
- 49, wherein the heavy chain polypeptide comprises:
- the amino acid sequence of SEQ ID NO:
- 180;
- the amino acid sequence of SEQ ID NO:
- 175;
- and
- the amino acid sequence of SEQ ID NO:
- 308;
- and
- a light chain polypeptide comprising the following CDRs:
- a light chain CDR1 that is a CDR1 in SEQ ID NO:
- 23;
- a light chain CDR2 that a CDR2 in SEQ ID NO:
- 23;
- and a light chain CDR3 that is a CDR3 in SEQ ID NO:
- 23, wherein the light chain polypeptide comprises:
- the amino acid sequence of SEQ ID NO:
- 395;
- the amino acid sequence of SEQ ID NO:
- 162;
- and
- the amino acid sequence of SEQ ID NO:
- 158.
Dependencies are inferred from the claim text.