SMMR (small molecule metabolite reporters) for use as in vivo glucose biosensors
AssigneeMasimo Laboratories, Inc.
InventorsEmile M. Bellott, Dongsheng Bu, James J. Childs, Christopher Lambert, Hubert A. Nienaber, Shirley J. Shi, Zhaolin Wang, Jerome J. Workman, Alex R. Zelenchuk
Life of this patent
Estimating the term…
Abstract
Small Molecule Metabolite Reporters (SMMRs) for use as in vivo glucose biosensors, sensor compositions, and methods of use, are described. The SMMRs include boronic acid-containing xanthene, coumarin, carbostyril and phenalene-based small molecules which are used for monitoring glucose in vivo, advantageously on the skin.
Claims11
A method of measuring a compound or metabolite thereof, comprising contacting a reporter compound of the following formula:
- wherein
- D is a heteroatom (O or N);
- R10 is H or CH3;
- R12 is
- wherein L is an amino-containing linking moiety;
- and
- at least one boronic acid moiety is present;
- and salts thereof, which reporter compound is sensitive to the presence of said compound or metabolite thereof, with an area of the body where said metabolites may be found, and detecting a photometric change in said reporter compound indicative of said compound or metabolite thereof.
A method of measuring a compound or metabolite thereof, comprising:
- contacting a reporter compound or a salt thereof with a sample of a biological fluid containing an amount of the compound or metabolite thereof;
- and
- detecting a photometric change in the reporter compound that is indicative of the compound or metabolite thereof;
- wherein the reporter compound has a structure represented by the following formula:
- Wherein:
- D is a heteroatom (O or N);
- R10 is H or CH3;
- R12 is
- wherein L is an amino-containing linking moiety;
- and
- at least one boronic acid moiety is present.
A compound having a structure represented by the following formula:
- wherein:
- D is a heteroatom (O or N);
- R10 is H or CH3;
- R12 is
- wherein L is an amino-containing linking moiety;
- and
- at least one boronic acid moiety is present.
Dependencies are inferred from the claim text.