Systems and methods for treating disorders of the central nervous system by modulation of brain networks

An implantable neurostimulation device comprising:

• a sensing subsystem including a first and a second electrode configured for sensing data from a first and a second region of a brain network, said brain network being identified as related to a disorder of the central nervous system;
• a stimulation subsystem configured for stimulating at least a first region of the brain network,
• a processor subsystem configured to operate a therapy program the therapy program configured for providing therapy of the brain network by evaluating sensed data to detect network events and adjusting stimulation as a function of the detected network events
• wherein network events are detected by an evaluation protocol which evaluates the sensed data in relation to defined treatment criteria that define at least one network event.

An implantable neurostimulation system including:

• a sensing subsystem including a first sensor configured for sensing data from at least one of a first and a second region of a brain network
• a stimulation subsystem configured for stimulating at least a first region of a brain network,
• a processor subsystem configured to operate a therapy program the therapy program configured for providing therapy of the brain network, the therapy program comprising:
• a sensing protocol configured to operate the sensing subsystem and obtain sensed data;
• an evaluation protocol configured to detect a network event by evaluating the sensed data in relation to a defined treatment criterion that defines a network event;
• and,
• a stimulation protocol configured for adjusting stimulation provided by the stimulation subsystem as a function of the detected network event;
• wherein the network event is defined using data associated with at least two brain regions of the brain network.