Processes for the preparation of optically active intermediates
AssigneeAstraZeneca AB
InventorsMasaru Mitsuda, Tadashi Moroshima, Kentaro Tsukuya, Kazuhiko Watabe, Masahiko Yamada
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Abstract
This invention relates to processes for the production of optically active 2-(disubstituted aryl)cyclopropylamine compounds and optically active 2-(disubstituted aryl)cyclopropane carboxamide compounds which are useful intermediates for the preparation of pharmaceutical agents, and in particular the compound [1S-(1α,2α,3β(1S*,2R*),5β)]-3-[7-[2-(3,4-difluorophenyl)-cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)-cyclopentane-1,2-diol.
Claims2
An optically active 2-aryl cyclopropane carboxamide compound represented by general formula (17)
- wherein, R10 is 3,4-difluorophenyl group, and * denotes an asymmetric carbon centre.
Dependencies are inferred from the claim text.