1,2,3-triazole bound borane compounds, synthesis of, and use in reduction reactions

Abstract

A 1,2,3-triazole coordinated borane such as where the B and the R3 groups can be on any of the three N positions and R1, R2, R3, R4, and R5 can be one or more of H, any alkyl, aryl, or substituted alkyl or aryl groups and the position of the final products are the combination of any N position; i.e. N1—R3—N3—BH etc. The triazole-borane compounds can be synthesized in a single-step from simple organic molecules under mild reactions. The 1,2,3-triazole coordinated borane can be synthesized by use of about a 1 to 1 equivalent of the benzole-triazole and the BR3 can be added together without solution or dissolved in an organic solvent (between about 5 M to about 0.001 M for each reactant). The solution can be stirred for about 1 to about 5 hours at an effective temperature to yield the triazole-borane. These compounds can be used as an effective reductant in a reduction reaction for one or more of the groups aldehyde, ketone, imine, and reductive coupling between aldehyde/ketone with amine (both primary and secondary) in a wide range of media.

Dependencies are inferred from the claim text.