Hydroxamates as therapeutic agents

A compound of Formula (I):

• wherein:
• R1 is hydrogen or alkyl;
• X is —O—, —NR2—, or —S(O)n where n is 0-2 and R2 is hydrogen or alkyl;
• Y is alkylene optionally substituted with cycloalkyl, optionally substituted phenyl, alkylthio, alkylsulfinyl, alkysulfonyl, optionally substituted phenylalkylthio, optionally substituted phenylalkylsulfonyl, hydroxyl, or optionally substituted phenoxy;
• Ar1 is phenylene or heteroarylene wherein said Ar1 is optionally substituted with one or two groups independently selected from alkyl, halo, hydroxyl, alkoxy, haloalkoxy, or haloalkyl;
• R3 is hydrogen, alkyl, hydroxyalkyl, or optionally substituted phenyl;
• and
• Ar2 is benzoxazol-2-yl;
• wherein benzoxazol-2-yl is optionally substituted with one or two substituents independently selected from alkyl, halo, haloalkyl, alkoxy, alkoxyalkyl, hydroxyalkoxy, hydroxyalkoxyalkyl, alkoxyalkyloxy, alkoxyalkyloxyalkyl, aminoalkyl, aminoalkoxy, haloalkoxy, haloalkoxyalkyl, optionally substituted phenylalkyl, optionally substituted phenyloxyalkyl, optionally substituted heteroaryl, optionally substituted heteroaralkyloxy, optionally substituted heteroaryloxyalkyl, optionally substituted heterocycloalkylalkyl, optionally substituted heterocycloalkyloxy, optionally substituted heterocycloalkylalkyloxy, -alkylene-S(O)nRa (where n is 0 to 2 and Ra is hydroxyalkyl or optionally substituted phenyl), -alkylene-NRe-alkyleneCONReRd (where Re is hydroxyl and Rd and Re are independently hydrogen or alkyl), or carboxyalkylaminoalkyl;
• or
• a pharmaceutically acceptable salt thereof.