Loading patent…
Assignee3M Innovative Properties Company
InventorsRyan B. Prince, Michael J. Rice, Joshua R. Wurst, Bryon A. Merrill, Tushar A. Kshirsagar, Philip D. Heppner
Estimating the term…
Thiazoloquinoline and thiazolonaphthyridine compounds having an aryloxy or arylalkyleneoxy substituent at the 6-, 7-, 8-, or 9-position, pharmaceutical compositions containing the compounds, intermediates, and methods of making and methods of use of these compounds as immunomodulators, for modulating cytokine biosynthesis in animals and in the treatment of diseases including viral and neoplastic diseases are disclosed.
A compound of formula (II):
A pharmaceutical composition comprising a therapeutically effective amount of a compound or salt of claim and a pharmaceutically acceptable carrier.
Dependencies are inferred from the claim text.
Drawings are temporarily unavailable. Open the PDF at USPTO
From the US filing history. Foreign family members aren’t listed.
In which the condensed system contains two hetero rings: ortho-condensed systems
In which the condensed system contains three hetero rings: ortho-condensed systems
Heterocyclic compounds
About 2 years 1 month of term left · ends 28 Nov 2028 (estimated)
In the 1950's the 1H-imidazo[4,5-c]quinoline ring system was developed, and 1-(6-methoxy-8-quinolinyl)-2-methyl-1H-imidazo[4,5-c]quinoline was synthesized for possible use as an antimalarial agent. Subsequently, syntheses of various substituted 1H-imidazo[4,5-c]quinolines were reported. For example, 1-[2-(4-piperidyl)ethyl]-1H-imidazo[4,5-c]quinoline was synthesized as a possible anticonvulsant and cardiovascular agent. Also, several 2-oxoimidazo[4,5-c]quinolines have been reported.
Certain 1H-imidazo[4,5-c]quinolin-4-amines and 1- and 2-substituted derivatives thereof were later found to be useful as antiviral agents, bronchodilators and immunomodulators. Subsequently, certain substituted 1H-imidazo[4,5-c]pyridin-4-amine, quinolin-4-amine, tetrahydroquinolin-4-amine, naphthyridin-4-amine, and tetrahydronaphthyridin-4-amine compounds as well as certain analogous thiazolo and oxazolo compounds were synthesized and found to be useful as immune response modifiers, rendering them useful in the treatment of a variety of disorders.
But despite important progress in the effort to find immunomodulating compounds, there is still a critical scientific and medical need for additional compounds that have an ability to modulate aspects of the immune response, by induction of cytokine biosynthesis or other mechanisms.
The present invention provides compounds of the following Formula (I):
as well as more specific compounds of the following Formulas (II, III, IV, V, VI, IIIa, IVa, VIa, and VII):
wherein RA, RB, R, R2, R3, G, and n are as defined below, and pharmaceutically acceptable salts thereof.