Process for producing coelenteramide or an analog thereof
AssigneeJnc Corporation
InventorInouye Satoshi
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Abstract
A process for producing coelenteramide or its analog in a high yield has been desired. The invention provides a process for producing di-O-methylcoelenteramide or its analog of formula (3) which comprises reacting O-methylcoelenteramine or its analog with 4-methoxyphenylacetyl halide or its analog. The invention also provides a process for producing coelenteramide or its analog, which comprises demethylation of di-O-methylcoelenteramide or its analog.
Claims14
A process for producing a compound represented by formula (3):
- wherein,
- R1 represents an alkyl having 1 to 3 carbon atoms or an arylalkyl having 7 to 10 carbon atoms,
- R3 represents (i) an alkyl having 1 to 7 carbon atoms which may optionally be substituted with an alicyclic group, (ii) an alicyclic group or (iii) an arylalkyl having 7 to 10 carbon atoms, and,
- R4 represents an alkyl having 1 to 3 carbon atoms or an arylalkyl having 7 to 10 carbon atoms, which comprises reacting a compound represented by formula (1):
- wherein R1 and R3 are as defined above, and, R2 is amino
- with a compound represented by formula (2):
- wherein X is a splitting-off group and R4 is as defined above.
A process for producing the compound:
- which comprises reacting the compound:
- with the compound:
A process for producing a compound represented by formula (4):
- wherein R3 represents (i) an alkyl having 1 to 7 carbon atoms which may optionally be substituted with an alicyclic group, (ii) an alicyclic group or (iii) an arylalkyl having 7 to 10 carbon atoms,
- which comprises splitting-off a group shown by R1 wherein R1 represents an alkyl having 1 to 3 carbon atoms or an arylalkyl having 7 to 10 carbon atoms and a group shown by R4 wherein R4 represents an alkyl having 1 to 3 carbon atoms or an arylalkyl having 7 to 10 carbon atoms from a compound represented by formula (3):
- wherein R1, R3 and R4 are as defined above.
A process for producing the compound:
- which comprises splitting-off methyl from the compound:
Dependencies are inferred from the claim text.