Recombinant plasmodium falciparum merozoite surface proteins 4 and 5 and their use
AssigneesInstitut Pasteur, Centre Nationale de la Recherche Scientifique
InventorsShirley Longacre, Hannah Polson, Ronald Perraut, Faridabano Nato
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Abstract
Accordingly, the invention provides constructs in which the nucleic acids encoding Plasmodium falciparum MSP4 and MSP5, and the resulting polypeptides, have been modified. More particularly, this invention provides constructs encoding recombinant MSP4 and MSP5 polypeptides, which are expressed as soluble, secreted polypeptides in a baculovirus-insect cell expression system. It was surprisingly found that the recombinant polypeptides contain an EGF-like domain at the C-terminus that is properly folded in the polypeptide.
Claims11
A purified nucleic acid molecule comprising SEQ ID NO:
- 7.
A purified nucleic acid molecule encoding an amino acid sequence comprising SEQ ID NO:
- 19 or 20.
A recombinant baculovirus deposited at the Collection Nationale de Cultures de Microorganismes (C.N.C.M.) under Accession No. I-3695.
A purified nucleic acid molecule consisting of SEQ ID NO:
- 7.
A purified nucleic acid molecule encoding an amino acid sequence consisting of SEQ ID NO:
- 19.
A purified nucleic acid molecule encoding an amino acid sequence consisting of SEQ ID NO:
- 20.
Dependencies are inferred from the claim text.