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US 8,026,346 B2Granted
Tribonectins
AssigneeRhode Island Hospital
InventorGregory D. Jay
Life of this patent
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Abstract
The invention features a tribonectin and a method of tribosupplementation carried out by administering tribonectins directly to an injured or arthritic joint.
Claims34
An isolated tribonectin polypeptide having a molecular weight of 280 kDa or less and comprising an amino acid sequence that comprises a multiplicity of subunits, wherein
- (a) each subunit comprises at least seven amino acids;
- (b) each subunit comprises at least one threonine and has an amino acid sequence that is at least 50% identical to SEQ ID NO:
- 3, wherein a non-identical amino acid is a conservative amino acid substitution;
- and one or more of said subunits comprising an O-linked β(1-3) Gal-GaINAc oligosaccharide.
1 more element
Dependencies are inferred from the claim text.