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US 8,026,286 B2Granted
Pharmaceutical compositions providing enhanced drug concentrations
AssigneeBend Research, Inc.
InventorsWilliam J. Curatolo, Ravi M. Shanker, Walter C. Babcock, Dwayne T. Friesen, James A. S. Nightingale, Douglas A. Lorenz
Life of this patent
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Abstract
A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.
Claims8
A composition comprising:
- (a) a drug in a pharmaceutically acceptable solubility-improved form that is a crystalline highly soluble salt form other than the crystalline hydrochloride salt;
- and
- (b) a concentration-enhancing polymer selected from the group consisting of cellulose acetate phthalate, cellulose acetate trimellitate, hydroxypropyl methyl cellulose phthalate, and hydroxypropyl methyl cellulose acetate succinate
- wherein
- said drug alone has an aqueous solubility of up to about 1 to 2 mg/mL;
- and said composition is not a dispersion and said drug and said polymer are present as particles in a dry physical mixture.
3 more elements
A composition comprising:
- (a) a drug in a crystalline highly soluble salt form other than the crystalline hydrochloride salt;
- and
- (b) hydroxypropyl methyl cellulose acetate succinate
- wherein
- said composition is not a dispersion;
- said drug alone has an aqueous solubility up to about 1 to 2 mg/mL;
- and
- said crystalline highly soluble salt form and said hyroxypropylmethyl cellulose acetate succinate are present as particles in a dry physical mixture.
5 more elements
Dependencies are inferred from the claim text.