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US 8,026,271 B2Granted
Formulations of indol-3-yl-2-oxoacetamide compounds
AssigneeNational Health Research Institutes
InventorsTeng-Kuang Yeh, Chiung-Tong Chen, Yu-Sheng Chao
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Abstract
This invention relates to an oral formulation containing an effective amount of the compound of the following formula I: d-alpha-tocopheryl polyethylene glycol 1000 succinate (“TPGS”); and 2-(2-ethoxyethoxy)ethanol (“Transcutol”). R1 through R4 and n are defined herein. Also disclosed is a method of treating cancer by administering this formula to a subject orally.
Claims16
A pharmaceutical formulation comprising:
- 15-80% by weight d-alpha-tocopheryl polyethylene glycol 1000 succinate (“TPGS”);
- 20-30% by weight 2-(2-ethoxyethoxy)ethanol (“Transcutol”);
- and
- N-(3-methylisothiazol-5-yl)-2-[1-(3-methylisoxazol-5-ylmethyl)-1H-indol-3-yl]-2-oxoacetamide.
1 more element
Dependencies are inferred from the claim text.