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US 8,026,269 B2Granted
Isoindoline compounds and methods of making and using the same
AssigneeCelgene Corporation
InventorsGeorge W. Muller, Hon-Wah Man
Life of this patent
Estimating the term…
Abstract
The invention encompasses isoindoline compounds, pharmaceutical compositions comprising them, and methods of their use for the treatment, prevention or management of various diseases and disorders. Examples include, but are not limited to, cancer, inflammatory bowel disease and myelodysplastic syndrome.
Claims8
A method of inhibiting PDE IV comprising administering to a subject a compound of the following formula:
- or a pharmaceutically acceptable salt, solvate, or stereoisomer thereof.
A method of treating or managing a disease or disorder comprising administering to a patient a compound of the following formula:
- a pharmaceutically acceptable salt, solvate, or stereoisomer thereof, wherein the disease or disorder is arthritis, rheumatoid arthritis, inflammatory bowel disease, asthma, adult respiratory distress syndrome, chronic obstructive pulmonary disorder, atopic dermatitis, psoriasis, or Crohn's disease.
Dependencies are inferred from the claim text.