Treatment of length dependent neuropathy
AssigneeArcion Therapeutics, Inc.
InventorJames N. Campbell
Life of this patent
Estimating the term…
Abstract
Compositions, and methods of use thereof, are provided for the treatment of painful neuropathy by local or topical delivery of compounds that interact with α-adrenergic receptors, especially an alpha2 adrenergic agonist such as clonidine, to the entire painful area such that the need for systemic dosing is minimized. The compounds are delivered to or adjacent to painful areas in patients with painful length dependent neuropathy, and other neuropathies that affect the pain signaling fibers in the skin. A preferred compound for the treatment of patients with length dependent neuropathy is clonidine applied in a transdermal patch, gel, ointment, lotion, liposomal formulation, cream, or emulsion, wherein the concentration is sufficient to provide an effective dose in the painful area or immediately adjacent areas.
Claims14
A method for the treatment of painful length dependent neuropathy that is not sympathetically maintained in a patient in need thereof and having functional pain signaling primary afferent (sensory) fibers and their receptors comprising locally or topically administering to a site at or adjacent to painful areas in the patient having functional pain signaling primary afferent (sensory) fibers and their receptors, an effective amount of an alpha2-adrenergic agonist at the site of administration and not systemically, to reduce or alleviate pain from length dependent neuropathy or other neuropathy that results in pain associated with disease or damage to the pain signaling primary afferent (sensory) fibers or their receptor, that is not sympathetically maintained pain, wherein the alpha2-adrenergic agonist is a compound having the structure represented by formula I:
- wherein A4 may be selected from aryl, and heteroaryl, which may be substituted by one or more radicals selected from alkyl, branched alkyl, cycloalkyl, hydroxyl, alkoxy, cycloalkylalkyl, alkoxyalkyl, aryl, alkanoyl, alkoxycarbonyl, carboxyl, amino, cyano, halogen, thioalkyl, dialkylamino, arylamino, alkylsulfinyl, alkylsulfonyl, arylsulfinyl or arylsulfonyl;
- wherein X is selected from thio, imino, or methylene;
- wherein R7 is selected from hydrogen, lower alkyl, or oxygen-containing heterocycle;
- and wherein n is either 2 or 3;
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.