Therapeutic agents useful for treating pain
AssigneePurdue Pharma L.P.
InventorZhengming Chen
Life of this patent
Estimating the term…
Abstract
4-Tetrazolyl-4-phenylpiperidine Compounds, compositions comprising an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound, methods for treating or preventing pain or diarrhea in an animal comprising administering to an animal in need thereof an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound and methods for stimulating opioid-receptor function in a cell comprising contacting a cell capable of expressing an opioid receptor with an effective amount of a 4-Tetrazolyl-4-phenylpiperidine Compound are disclosed.
Claims18
A composition comprising a compound or a pharmaceutically acceptable salt of a compound of formula (Ia):
- wherein
- Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- G is —H, -L-(CH2)nC(O)OR4, -L-(CH2)nR5, —(C1-C5 alkylene)C(O)OR4, or —(C1-C5 alkylene)R5;
- L is —C(O)—, —S(O)2— or —S(O)—;
- R1 is —H, —C(O)NH2, —C(O)NHOH, —C(O)OR4, —C(O)H, —CN, —(C1-C4 alkyl), —C(O)NH(C1-C4 alkyl), or —C(O)N(C1-C4 alkyl)2;
- R2 and R3 are each independently -halogen, —C1-C3 alkyl, —O(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2;
- R4 is —H, —C1-C10 alkyl, —CH2O(C1-C4 alkyl), —CH2N(C1-C4 alkyl)2, or —CH2NH(C1-C4 alkyl);
- R5 is —NH2, —NHS(O)2R4, —C(O)NH2, —C(O)NHOH, —S(O)2NH2, —C(O)NH(C1-C4 alkyl), —C(O)N(C1-C4 alkyl)2, —S(O)2NH(C1-C4 alkyl), —S(O)2N(C1-C4 alkyl)2, —H, —OH, —CN, —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl, or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- m is an integer ranging from 0 to 4;
- n is an integer ranging from 1 to 4;
- p is 0 or 1;
- and
- q is an integer ranging from 0 to 3;
- a pharmaceutically acceptable carrier, and a therapeutic agent selected from an opioid analgesic, a non-opioid analgesic, an anti-emetic agent, and an anti-diarrheal agent.
A composition comprising a compound or a pharmaceutically acceptable salt of a compound of formula (Ib):
- wherein
- Ar1 is —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- Ar2 is phenyl, naphthyl, anthryl, phenanthryl or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- G is —H, -L-(CH2)nC(O)OR4, -L-(CH2)nR5, —(C1-C5 alkylene)C(O)OR4, or —(C1-C5 alkylene)R5;
- L is —C(O)—, —S(O)2— or —S(O)—;
- R1 is —H, —C(O)NH2, —C(O)NHOH, —C(O)OR4, —C(O)H, —CN, —(C1-C4 alkyl), —C(O)NH(C1-C4 alkyl), or —C(O)N(C1-C4 alkyl)2;
- R2 and R3 are each independently -halogen, —C1-C3 alkyl, —O(C1-C3 alkyl), —NH(C1-C3 alkyl) or —N(C1-C3 alkyl)2;
- R4 is —H, —C1-C10 alkyl, —CH2O(C1-C4 alkyl), —CH2N(C1-C4 alkyl)2, or —CH2NH(C1-C4 alkyl);
- R5 is —NH2, —NHS(O)2R4, —C(O)NH2, —C(O)NHOH, —S(O)2NH2, —C(O)NH(C1-C4 alkyl), —C(O)N(C1-C4 alkyl)2, —S(O)2NH(C1-C4 alkyl), —S(O)2N(C1-C4 alkyl)2, —H, —OH, —CN, —C3-C8 cycloalkyl, phenyl, naphthyl, anthryl, phenanthryl, or -(5- to 7-membered) heteroaryl, each being unsubstituted or substituted with one or more R2 groups;
- m is an integer ranging from 0 to 4;
- n is an integer ranging from 1 to 4;
- p is 0 or 1;
- and
- q is an integer ranging from 0 to 3;
- a pharmaceutically acceptable carrier, and a therapeutic agent selected from an opioid analgesic, a non-opioid analgesic, an anti-emetic agent, and an anti-diarrheal agent.
Dependencies are inferred from the claim text.