Pyrrole derivatives as pharmaceutical agents

The compound of formula (III);

• wherein:
• R1 is optionally substituted alkyl;
• R3 is independently hydrogen or optionally substituted alkyl;
• R4 is aryl, optionally substituted by one or more substituents selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, halo, haloalkyl, haloalkenyl, haloalkoxy, nitro, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkenyl, optionally substituted cycloalkenylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heteroaralkenyl, —R8—OR9, —R8—SR9, —R8—S(O)tR10 (where t is 1 or 2), —R8—N(R9)2, —R8—CN, —R8—C(O)R9, —R8—C(S)R9, —R8—C(NR9)R9, —R8—C(O)OR9, —R8—C(S)OR9, —R8—C(NR9)OR9, —R8—C(O)N(R9)2, —R8—C(S)N(R9)2, —R8—C(NR9)N(R9)2, —R8—C(O)SR9, —R8—C(S)SR9, —R8—C(NR9)SR9, —R8—S(O)tOR9 (where t is 1 or 2), —R8—S(O)tN(R9)2 (where t is 1 or 2), —R8—S(O)tN(R9)N(R9)2 (where t is 1 or 2), —R8—S(O)tN(R9)N═C(R9)2, —R8—S(O)tN(R9)C(O)R10 (where t is 1 or 2), —R8—S(O)tN(R9)C(O)N(R9)2 (where t is 1 or 2), —R8—S(O)tN(R9)C(NR9)N(R9)2 (where t is 1 or 2), —R8—N(R9)C(O)R10, —R8—N(R9)C(O)OR10, —R8—N(R9)C(O)SR10, —R8—N(R9)C(NR9)SR10, —R8—N(R9)C(S)SR10, —R8—N(R9)C(O)N(R9)2, —R8—N(R9)C(NR9)N(R9)2, —R8—N(R9)C(S)N(R9)2, —R8—N(R9)S(O)tR10 (where t is 1 or 2), —R8—OC(O)R10, —R8—OC(NR9)R10, —R8—OC(S)R10, —R8—OC(O)OR10, —R8—OC(NR9)OR10, —R8—OC(S)OR10, —R8—OC(O)SR9, —R8—OC(O)N(R9)2, —R8—OC(NR9)N(R9)2, —R8—OC(S)N(R9)2, —R8—C(O)—R11—C(O)R9, —R8-C(O)—R11—C(S)R9, —R8-C(O)—R11—C(NR9)R9, —R8-C(O)—R11—C(O)OR9, —R8-C(O)—R11—C(S)OR9, —R8-C(O)—R11—C(NR9)OR9, —R8—C(O)—R11—C(O)N(R9)2, —R8-C(O)—R11—C(S)N(R9)2, —R8-C(O)—R11—C(NR9)N(R9)2, —R8—C(O)—R11—C(O)SR9, —R8—C(O)—R11—C(S)SR9 and —R8—C(O)—R11—C(NR9)SR9;
• R5 is alkyl optionally substituted by one or more substituents selected from the group consisting of halo, haloalkyl, haloalkoxy, nitro, —OR9, —SR9, —S(O)tR10 (where t is 1 or 2), —N(R9)2, —CN, —C(O)R9, —C(S)R9, —C(NR9)R9, —C(O)OR9, —C(S)OR9, —C(NR9)OR9, —C(O)N(R9)2, —C(S)N(R9)2, —C(NR9)N(R9)2, —C(O)SR9, —C(S)SR9, —C(NR9)SR9, —S(O)tOR9 (where t is 1 or 2), —S(O)tN(R9)2 (where t is 1 or 2), —S(O)tN(R9)N(R9)2 (where t is 1 or 2), —S(O)tN(R9)N═C(R9)2, —S(O)tN(R9)C(O)R10 (where t is 1 or 2), —S(O)tN(R9)C(O)N(R9)2 (where t is 1 or 2), —R8-S(O)tN(R9)C(NR9)N(R9)2 (where t is 1 or 2), —N(R9)C(O)R10, —N(R9)C(O)OR10, —N(R9)C(O)SR10, —N(R9)C(NR9)SR10, —N(R9)C(S)SR10, —N(R9)C(O)N(R9)2, —N(R9)C(NR9)N(R9)2, —N(R9)C(S)N(R9)2, —N(R9)S(O)tR10 (where t is 1 or 2), —OC(O)R10, —OC(NR9)R10, —OC(S)R10, —OC(O)OR10, —OC(NR9)OR10, —OC(S)OR10, —OC(O)SR9, —OC(O)N(R9)2, —OC(NR9)N(R9)2, —OC(S)N(R9)2, —C(O)—R11—C(O)R9, —C(O)—R11—C(S)R9, —C(O)—R11—C(NR9)R9, —C(O)—R11—C(O)OR9, —C(O)—R11—C(S)OR9, —C(O)—R11—C(NR9)OR9, —C(O)—R11—C(O)N(R9)2, —C(O)—R11—C(S)N(R9)2, —C(O)—R11—C(NR9)N(R9)2, —C(O)—R11—C(O)SR9, —C(O)—R11—C(S)SR9 and —C(O)—R11—C(NR9)SR9;
• R6 is hydrogen or optionally substituted alkyl;
• R7 is aryl, optionally substituted by one or more substituents selected from the group consisting of optionally substituted alkenyl, optionally substituted alkynyl, halo, haloalkyl, haloalkenyl, haloalkoxy, nitro, dioxo, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted cycloalkenyl, optionally substituted cycloalkenylalkyl, optionally substituted aralkyl, optionally substituted aralkenyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heterocyclylalkenyl, optionally substituted heteroaryl, optionally substituted heteroaralkyl, optionally substituted heteroaralkenyl, —R13—OR14, —R13—SR14, —R13—S(O)tR18 (where t is 1 or 2), —R13—N(R14)2, —R13—CN, —R13—C(O)R14, —R13—C(S)R14, —R13—C(NR14)R14, —R13—C(S)OR14, —R13—C(NR14)OR14, —R13—C(S)N(R14)2, —R13—C(NR14)N(R14)2, —R13—C(O)SR14, —R13—C(S)SR14, —R13—C(NR14)SR14, —R13—S(O)tOR14 (where t is 1 or 2), —R13—S(O)tN(R14)2 (where t is 1 or 2), —R13—S(O)tN(R14)N(R14)2 (where t is 1 or 2), —R13—S(O)tN(R14)N═C(R14)2, —R13—S(O)tN(R14)C(O)R18, —R13—S(O)tN(R14)C(O)N(R14)2 (where t is 1 or 2), —R13—S(O)tN(R14)C(NR14)N(R14)2 (where t is 1 or 2), —R13—N(R14)C(O)R15, —R13—N(R14)C(O)OR18, —R13—N(R14)C(O)SR15, —R13—N(R14)C(NR14)SR15, —R13—N(R14)C(S)SR15, —R13—N(R14)C(O)N(R14)2, —R13—N(R14)C(NR14)N(R14)2, —R13—N(R14)C(S)N(R14)2, —R13—N(R14)S(O)tR18 (where t is 1 or 2), —R13—OC(O)R15, —R13—OC(NR14)R15, —R13—OC(S)R15, —R13—OC(O)OR18, —R13—OC(NR14)OR18, —R13—OC(S)OR18, —R13—OC(O)SR14, —R13—OC(O)N(R14)2, —R13—OC(NR14)N(R14)2, —R13—OC(S)N(R14)2—R13—C(O)—R16—C(O)R14, —R13—C(O)—R16—C(S)R14, —R13—C(O)—R16—C(NR14)R14, —R13C(O)—R18—C(O)OR14, —R13—C(O)—R18—C(S)OR14, —R13—C(O)—R18—C(NR14)OR14, —R13—C(O)—R16—C(O)N(R14)2, —R13—C(O)—R16—C(S)N(R14)2, —R13—C(O)—R16C(NR14)N(R14)2, —R13—C(O)—R16—C(O)SR14, —R13—C(O)—R16—C(S)SR14 and —R13—C(O)—R16—C(NR14)SR14;
• where each R8 and R13 are independently a direct bond, an optionally substituted straight or branched alkylene chain, or an optionally substituted straight or branched alkenylene chain;
• where each R9 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroaralkyl;
• or
• where two R9s, together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclyl;
• where each R14 is independently selected from the group consisting of hydrogen, optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroaralkyl;
• or
• where two R14s, together with the nitrogen atom to which they are attached, form an optionally substituted heterocyclyl;
• where each R10 and R15 are independently selected from the group consisting of optionally substituted alkyl, optionally substituted alkenyl, optionally substituted alkynyl, optionally substituted cycloalkyl, optionally substituted cycloalkylalkyl, optionally substituted aryl, optionally substituted aralkyl, optionally substituted heterocyclyl, optionally substituted heterocyclylalkyl, optionally substituted heteroaryl and optionally substituted heteroaralkyl;
• and
• where each R11 and R16 are independently an optionally substituted straight or branched alkylene chain or an optionally substituted straight or branched alkenylene chain;
• or as a pharmaceutically acceptable salt thereof.