US 8,026,235 B1Granted

Pyridyl benzoxazine derivatives, pharmaceutical composition comprising the same, and use thereof

AssigneeDaewoong Pharmaceutical Co., Ltd.

InventorsJi Duck Kim, Hong-Chul Yoon, In Woo Kim, Min Jae Cho, In Young Lee, Sang Ho Lee, Eun Kyung Park, Kwon Jo Lim, Sang Hyun Nam

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Abstract

Discloses is a benzoxazine benzimidazole derivative, represented by Chemical Formula 1, functioning as an antagonist to the vanilloid receptor-1, a pharmaceutical composition comprising the same, and the use thereof. The benzoxazine benzimidazole derivative can be useful for preventing or treating a disease associated with antagonistic activity of vanilloid receptor-1, without hyperthermia: wherein, R1, R2, R3, R4 and R5 are as defined in the specification.

Claims13

Dependent claims

A compound, represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof:

wherein,
R1 is hydrogen or C1-3 hydroxyalkyl;
R2 is hydrogen or halogen;
R3 is hydrogen or halogen;
R4 is hydrogen, halogen, C1-4 alkyl, C1-3 haloalkyl or C1-3 haloalkoxy;
and
R5 is C1-4 alkyl.

4 more elements

Dependencies are inferred from the claim text.

Facts

Application: 12/909,513Filed 21 Oct 2010
Priority: KR 10-210-009991013 Oct 2010
Granted: 27 Sep 2011
Term ends: Not estimatedThe source records don’t support an estimate.

Classification24 codes

C07D 413/14
Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms:…
A61P 1/04
Drugs for disorders of the alimentary tract or the digestive system: for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of…
A61P 1/08
Drugs for disorders of the alimentary tract or the digestive system: for nausea, cinetosis or vertigo; Antiemetics
A61P 3/04
Drugs for disorders of the metabolism: anorexiants; Antiobesity agents