Chemoprotective methods and compositions
AssigneeBioNumerik Pharmaceuticals, Inc.
InventorFrederick H. Hausheer
Life of this patent
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Abstract
Compositions and methods for reducing, preventing, mitigating, and/or delaying the onset of, attenuating the severity of, and/or hastening the resolution of, for example, one or more chemotherapy-associated toxicities in a subject receiving one or more chemotherapeutic agents.
Claims159
A method of reducing, alleviating, mitigating, or delaying toxicity in a subject receiving a chemotherapeutic agent, comprising administering to the subject in need thereof a pharmaceutically-effective amount of 2,2′-dithio-bis-ethane sulfonate at a rate of about 0.1 g/min. to about 2.0 g/min.
A method of reducing, alleviating, mitigating, or delaying toxicity in a subject receiving a chemotherapeutic agent, comprising administering to said subject in need thereof a pharmaceutically-effective amount of 2,2′-dithio-bis-ethane sulfonate at a rate of about 1 mg/mL/min. to about 50 mg/mL/min.
A method of reducing, alleviating, mitigating or delaying toxicity in a subject receiving a chemotherapeutic agent, comprising administering to said subject in need thereof a composition comprising a pharmaceutically-effective amount of 2,2′-dithio-bis-ethane sulfonate, wherein said composition has an osmolarity of about 0.1- to about 5-times the osmolarity of the normal plasma of said subject.
A method of reducing, alleviating, mitigating, or delaying toxicity in a subject receiving a chemotherapeutic agent, comprising administering to said subject in need thereof a pharmaceutically-effective amount of a 2,2′-dithio-bis-ethane sulfonate at a rate of about 0.1 g/min to about 4.6 g/min, at a total dose of about 4 g/m2 to about 35 g/m2.
Dependencies are inferred from the claim text.