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US 8,026,220 B2Granted
C-linked glucuronide of N-(4-hydroxybenzyl) retinone, analogs thereof, and method of using the same to inhibit neoplastic cell growth
AssigneeWisconsin Alumni Research Foundation
InventorsMargaret Clagett-Dame, Robert W. Curley, Jr., Joel R. Walker, Hussein Abou-Issa, Galal A. Alshafie
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Abstract
Compounds of the formula: are described, along with pharmaceutical compositions containing these compounds, and methods of using the compounds to prevent and to treat cancer in mammals, including humans.
Claims6
A compound of Formula I:
- wherein X is CH2;
- Y is C1-C6 alkylene;
- R is C1-C6 alkyl;
- and R2 is selected from the group consisting of H and ═O;
- or a salt thereof.
2 more elements
A compound of Formula I:
- wherein X is CH2;
- Y is C1-C6 alkylene;
- and R is selected from the group consisting of hydrogen, C1-C6 alkyl, and
- wherein R1 is selected from the group consisting of OH, C1-C6 alkyl, alkenyl, and alkynyl;
- and R2 is selected from the group consisting of H and ═O;
- or a salt thereof.
3 more elements
Dependencies are inferred from the claim text.