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US 8,026,110 B2Granted
Combinatorial rosamine library and uses thereof
AssigneeNew York University
InventorsYoung-Tae Chang, Young-Hoon Ahn
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Abstract
The present invention relates to a rosamine derivative compound, as described herein, having the following structure: Also disclosed are methods of making such compounds and for using them for detection and imaging.
Claims25
A rosamine derivative compound of the formula:
- wherein:
- X is O, NR4, or S;
- R1 is NR4R5, OH, NR4R6, or
- R2 is substituted or unsubstituted napthyl,
- wherein the substituted form of R2 has one or more substituents independently selected from the group consisting of halogen, NR4R5, OR7, SR4, aryl,
- R3 is H or with R1 collectively forms a fused ring of the structure of
- R4 is H or C1 to C6 alkyl;
- R5 is H, C1 to C6 alkyl, or with R4 collectively forms a ring structure;
- R6 is (CH2)nNR4R8;
- R7 is H, C1 to C6 alkyl, or aryl;
- R8 is H or C1 to C6 alkyl;
- Y is alkyl or halogen;
- n is 1 to 3;
- m is 0 to 3;
- and
- * is a site on a substituent which binds to the rosamine derivative compound.
13 more elements
A rosamine derivative compound of the formula:
- wherein:
- X is O, NR4, or S;
- R1 is NR4R5, OH, NR4R6, or
- R2 is substituted or unsubstituted napthyl,
- wherein the substituted form of R2 has one or more substituents independently selected from the group consisting of halogen, NR4R5, OR7, SR4, aryl, C1 to C6 alkyl,
- R3 is H or with R1 collectively forms a fused ring of the structure of
- R4 is H or C1 to C6 alkyl;
- R5 is H, C1 to C6 alkyl, or with R4 collectively forms a ring structure;
- R6 is (CH2)nNR4R8;
- R7 is H, C1 to C6 alkyl, or aryl;
- R8 is H or C1 to C6 alkyl;
- Y is alkyl or halogen;
- n is 1 to 3;
- m is 0 to 3;
- and
- * is a site on a substituent which binds to the rosamine derivative compound.
13 more elements
Dependencies are inferred from the claim text.