Yarrowia lipolytica and Pichia pastoris HAC1 nucleic acids
AssigneesOxyrane UK Limited, Vib Vzw, Universiteit Gent
InventorsNico Luc Marc Callewaert, Wouter Vervecken, Karen Jacqueline Marcel De Pourcq, Steven Christian Jozef Geysens, Mouna Guerfal
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Abstract
Described herein are methods and genetically engineered cells useful for producing an altered N-glycosylation form of a target molecule. Also described are methods and molecules with altered N-glycosylation useful for treating a variety of disorders such as metabolic disorders.
Claims22
An isolated nucleic acid comprising:
- (a) the nucleotide sequence set forth in SEQ ID NO:1;
- (b) a nucleotide sequence that hybridizes under highly stringent conditions to the complement of the nucleotide sequence set forth in SEQ ID NO:1;
- or
- (c) the complement of the nucleotide sequence set forth in SEQ ID NO:1.
An isolated nucleic acid comprising a nucleotide sequence that is at least 90% identical to SEQ ID NO:1.
An isolated nucleic acid comprising:
- (a) the nucleotide sequence set forth in SEQ ID NO:2;
- (b) a nucleotide sequence that hybridizes under highly stringent conditions to the complement of SEQ ID NO:2;
- or
- (c) the complement of the nucleotide sequence set forth in SEQ ID NO:2.
An isolated nucleic acid comprising a nucleotide sequence that is at least 90% identical to SEQ ID NO:2.
Dependencies are inferred from the claim text.