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US 8,026,074 B2Granted
Methods of using GPR119 to identify compounds useful for increasing bone mass in an individual
AssigneeArena Pharmaceuticals, Inc.
InventorsZhi-Liang Chu, James N. Leonard
Life of this patent
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Abstract
The present invention relates to methods of using GPR119 receptor to identify compounds useful for increasing bone mass in an individual. Agonists of GPR119 receptor are useful as therapeutic agents for treating or preventing a condition characterized by low bone mass, such as osteoporosis, and for increasing bone mass in an individual. Agonists of GPR119 receptor promote bone formation in an individual.
Claims17
A method of identifying a glucose-dependent insulinotropic peptide (GIP) secretagogue, comprising:
- (a) contacting, in vitro, a G protein-coupled receptor 119 (GPR119) agonist with a vertebrate enteroendocrine cell or with a cell capable of secreting GIP, and
- (b) determining whether the GPR119 agonist stimulates GIP secretion from the vertebrate enteroendocrine cell or from the cell capable of secreting GIP;
- wherein the ability of the GPR119 agonist to stimulate GIP secretion from the vertebrate enteroendocrine cell or from the cell capable of secreting GIP is indicative of the agonist being a GIP secretagogue.
Dependencies are inferred from the claim text.