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US 8,025,900 B2Granted
Sustained release composition of protein drug
AssigneeLG Life Science Ltd.
InventorsSuk Young Choi, Hoon Sung Jeh
Life of this patent
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Abstract
Disclosed is a sustained release composition of a protein drug. The composition comprises a carrier substrate and a protein drug incorporated in the carrier substrate. The carrier substrate is consisting essentially of a hyaluronic acid or its salts, an amino acid, and a polyalkyl oxide.
Claims19
A sustained release composition comprising
- a carrier substrate and
- a protein drug incorporated into the carrier substrate,
- said carrier substrate comprising
- (a) a hyaluronic acid or its salt, having a molecular weight of at least 3,000,000 Da,
- (b) a polyalkyl oxide, and
- (c) an amino acid wherein the amino acid is selected from the group consisting of aspartic acid, histidine, isoleucine, leucine, methionine, valine and a combination or at least two of the foregoing amino acids,
- wherein a ratio of a molecular weight (Da) of the protein drug to a molecular weight (Da) of the polyalkyl oxide is about 1:0.5-1:1.8
4 more elements
A sustained release composition comprising
- a carrier substrate and
- a protein drug incorporated into the carrier substrate,
- said carrier substrate being comprising
- (a) a hyaluronic acid or its salt having molecular weight of at least 3,000,000 Da,
- (b) a polyethylene glycol, and
- (c) an amino acid selected from the group consisting of aspartic acid, histidine, isoleucine, leucine, methionine, valine, and a combination of at least two of the foregoing amino acids,
- wherein a ratio of a molecular weight (Da) of the protein drug to a molecular weight (Da) of the polyethylene glycol is about 1:0.8-1:1.8 and the molecular weight of the polyethylene glycol is at least 1,000 Da.
4 more elements
Dependencies are inferred from the claim text.