Ibuprofen composition
AssigneeMcNeil-PPC, Inc.
InventorsFrank J. Bunick, Feng Lin
Life of this patent
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Abstract
Fumaric acid is added in amounts sufficient to reduce the burn sensation commonly associated with propionic acid derivatives.
Claims7
An orally administered composition comprising a therapeutically effective amount of a racemic mixture of a propionic acid derivative selected from the group consisting of ibuprofen, naproxen, benoxaprofen, naproxen sodium, flurbiprofen, fenoprofen, fenbuprofen, ketoprofen, indoprofen, pirprofen, carpofen, oxaprofen, pranoprofen, microprofen, tioxaprofen, suproprofen, alminoprofen, tiaprofenic acid, fluprofen, bucloxic acid and their salts thereof, wherein the composition contains from about 50 to about 150 weight percent fumaric acid based upon the weight of the racemic mixture of the propionic acid derivative, the propionic acid derivative provided as a plurality of particles coated with a hydrocolloid;
- provided that no fumaric acid is incorporated in the hydrocolloid coating on the particles or granules of the propionic acid derivative, and wherein the level of the fumaric acid is from about 7% to about 13% by weight of the total composition weight.
Dependencies are inferred from the claim text.