Porous extracellular matrix scaffold and method
AssigneeDePuy Products, Inc.
InventorsPrasanna Malaviya, Herbert E. Schwartz, Pamela L. Plouhar, Mark J. Pelo
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Abstract
A method of making an implantable scaffold for repairing damaged or diseased tissue includes the step of suspending pieces of an extracellular matrix material in a liquid. The extracellular matrix material and the liquid are formed into a mass. The liquid is subsequently driven off so as to form interstices in the mass. Porous implantable scaffolds fabricated by such a method are also disclosed.
Claims10
A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
- cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers;
- and
- freeze drying the cohesive mass to form a porous structure.
A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
- providing a naturally occurring extracellular matrix material selected from the group consisting of:
- small intestine submucosa, stomach submucosa, bladder submucosa, respiratory submucosa, alimentary submucosa, genital submucosa, and liver basement membrane;
- cutting the naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers;
- and
- freeze drying the cohesive mass to form a porous structure.
A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
- cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers,
- freezing the cohesive mass at a controlled rate of temperature drop, and
- freeze drying the cohesive mass to form a porous structure,
- wherein the cohesive mass is frozen by reducing the temperature of the naturally occurring extracellular matrix at a rate of −1° C./min or less.
A method of making an implantable scaffold for repairing or regenerating body tissue, the method comprising the steps of:
- cutting naturally occurring extracellular matrix material in the presence of a liquid to produce a cohesive mass of intertwined strips, ribbons, or fibers,
- freezing the cohesive mass at a controlled rate of temperature drop, and
- freeze drying the cohesive mass to form a porous structure,
- wherein the cohesive mass is frozen by reducing the temperature of the naturally occurring extracellular matrix at a rate of greater than −1° C./min.
Dependencies are inferred from the claim text.