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US 8,025,891 B2Granted
Porin B (PorB) as a therapeutic target for prevention and treatment of infection by Chlamydia
AssigneeThe Regents of the University of California
InventorsRichard S. Stephens, Diane Kawa
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Abstract
The present invention features peptides of a PorB polypeptide, which PorB peptides are useful in production of antibodies that bind the full-length PorB polypeptide and as a therapeutic agent. In specific embodiments the invention features a composition comprising one or more PorB peptides (other than a full-length PorB polypeptide), which peptides contain at least one epitope that can elicit Chlamydia-neutralizing antibodies. The invention also features methods for induction of a protective immune response against infection by Chlamydia and Chlamydophila.
Claims14
A composition comprising:
- an isolated polypeptide up to 60 amino acids in length, wherein the isolated polypeptide contains an amino acid sequence of SEQ ID NO:
- 13 (DLVNCNLNTNCVAVAFSLPD), or an amino acid sequence of SEQ ID NO:
- 13 comprising at least one conservative amino acid substitution, wherein the isolated polypeptide binds to neutralizing C. trachomatis PorB polypeptide-specific antisera;
- and
- a pharmaceutically acceptable carrier.
2 more elements
Dependencies are inferred from the claim text.