Use of a chromatography substrate for reducing the amount of ADAMTS13 in a solution derived from plasma
AssigneeLfb Biotechnologies
InventorsFrancoise Bridey, Roland Schmitthaeusler
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Abstract
An ion-exchange chromatography support for reducing the ADAMTS13 amount present in a plasma-derived solution containing human von Willebrand factor. The support includes a large-pore, vinyl polymer-type resin bearing DEAE groups, and a buffer including trisodium citrate, sodium chloride, calcium chloride, glycine and lysine.
Claims8
A method for reducing the ADAMTS13 amount in a solution derived from human vWF-containing plasma comprising an ion-exchange chromatography step on a large-pore, vinyl polymer-type resin bearing DEAE groups, performed in a buffer comprising trisodium citrate, sodium chloride, calcium chloride, glycine and lysine.
Dependencies are inferred from the claim text.