Bioabsorbable implantable structure
AssigneeThe Queen's University of Belfast
InventorFraser James Buchanan
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Abstract
Provided is a method of producing a bioabsorbable, implantable substrate having a graded molecular weight distribution, comprising exposing at least a portion of the implantable substrate to electron beam irradiation. There is also provided a bioabsorbable, implantable substrate comprising a bioabsorbable polymer having a graded molecular weight distribution through at least a portion of its thickness.
Claims11
A bioabsorbable, implantable substrate comprising an outer surface and a core, said implantable substrate having a molecular weight distribution that changes gradually from the outer surface to the core wherein the average molecular weight at the core is greater than the average molecular weight at the entire outer surface, the entire surface of the implantable substrate having been exposed to electron beam irradiation to reduce the molecular weight distribution of said entire surface, wherein the rate of bioabsorbability of the core is less than the rate of bioabsorbability of the entire outer surface.
A method of producing a bioabsorbable, implantable substrate comprising an outer surface and a core, wherein the molecular weight distribution of the implant changes gradually from the outer surface to the core, the average molecular weight at the core is greater than the average molecular weight at the entire outer surface, and the rate of bioabsorbability of the core is less than the rate of bioabsorbability of the entire outer surface, said method comprising the steps of providing an implantable substrate and exposing the entire surface of the implantable substrate to electron beam irradiation to reduce the molecular weight distribution of said entire surface.
Dependencies are inferred from the claim text.