Amino derivatives of beta-homoandrostanes and beta-heteroandrostanes

A compound of formula (I):

• wherein:
• A is a divalent group selected from the group consisting of
• wherein the symbols indicate α or β single bonds which connect the A group to the androstane skeleton at position 5 or 8;
• B is oxygen or NR4, wherein R4 is H, C1-C6 alkyl group, or formyl when A is
• R3 is H or C1-C6 alkyl group;
• X is oxygen, sulphur or NOR5;
• R5 is H or C1-C6 alkyl group;
• R1 is H, C1-C6 alkyl group or C2-C6 acyl group when the bond in position 17 of the androstane skeleton is a single bond;
• or
• R1 is not present when the bond in position 17 is a double bond;
• R2 is DNR6R7 or the group
• wherein D or Z is linked to the oxygen atom;
• D is a C2-C6 linear or branched alkylene or a C3-C6 cycloalkylene, optionally containing a phenyl ring;
• R6 and R7 are the same or different and are H, C1-C6 alkyl, phenyl-C1-C4 alkyl or C(═NR9)NHR10;
• or
• R6 and R7, taken together with the nitrogen atom to which they are linked, form an unsubstituted or substituted saturated or unsaturated mono heterocyclic 4-, 5- or 6- membered ring, optionally containing another heteroatom selected from the group consisting of oxygen, sulphur and nitrogen;
• or
• R6 and R7 are optionally substituted with one or more hydroxy, methoxy, or ethoxy groups;
• or
• one of R6 and R7 is C(═NR9)NHR10 and the other is H;
• R8 is H, C1-C6 linear or branched alkyl, optionally substituted with one or more hydroxy, methoxy, ethoxy, or C(═NR9)NHR10;
• R9 and R10 are the same or different and are H, C1-C6 linear or branched alkyl group;
• or
• R9 and R10, taken together with the nitrogen atoms and the guanidinic carbon atom, form an unsubstituted or substituted saturated or unsaturated mono heterocyclic 5- or 6-membered ring optionally containing another heteroatom selected from the group consisting of oxygen, sulphur and nitrogen;
• Z is a C1-C4 linear or branched alkylene or a single bond;
• Y is CH2, oxygen, sulphur or NR11;
• R11 is H, or C1-C6, alkyl group;
• n is 0, 1, 2 or 3;
• m is 0, 1, 2 or 3;
• the symbol in position 17 is, independently, a single or double bond, and when it is a single exocyclic bond in position 17, it is an α or β single bond.