Inhibition of PPAR gamma expression by specific osteogenic oxysterols
AssigneeThe Regents of the University of California
InventorsFarhad Parhami, Woo-Kyun Kim, Michael E. Jung, Khanhlinh Nguyen
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Abstract
This invention relates to methods for using agents to inhibit peroxisome proliferator activated receptor expression.
Claims19
A method for inhibiting expression of a peroxisome proliferator activated receptor (PPAR) in a cell, comprising:
- contacting at least one oxysterol compound with the cell in an amount effective to inhibit expression of the PPAR;
- and
- measuring inhibition of expression of the PPAR.
A method of treating a condition associated with increased adipogenesis in a subject, comprising administering to the subject an amount of an oxysterol compound effective to treat the condition, wherein the oxysterol compound has been shown to be in an amount that is effective to inhibit PPAR expression.
A method of treating a condition associated with excessive accumulation of intracellular and/or extracellular fats and/or lipids in a subject, comprising administering to the subject an amount of an oxysterol compound effective to treat the condition, wherein the oxysterol compound has been shown to be in an amount that is effective to inhibit PPAR expression.
A method for identifying an oxysterol compound that inhibits expression of PPAR, comprising:
- screening a candidate oxysterol compound for the ability to inhibit expression of PPAR in an in vitro assay;
- and
- selecting a candidate oxysterol compound that measurably inhibits PPAR expression.
Dependencies are inferred from the claim text.