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US 8,021,696 B2Granted
Anti-inflammatory dissolvable film
AssigneeIzun Pharmaceuticals Corp.
InventorsZvi G. Loewy, William Zev Levine, Aron J. Saffer
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Abstract
Provided, among other things, is a slowly dissolvable film comprising: herbal bioactive agent(s); and polymer(s), dissolvable in the aggregate, wherein the film becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom.
Claims12
A dissolvable film comprising:
- a) an antiinflammatory amount of an extract of Sambucus nigra and one or more of a second extract of Allium sativum, Camellia sinensis, Centella asiatica, Commiphora molmol, Echinacea purpurea, Gaultheria procumbens, Hypericum perforatum, Krameria triandra, Ligusticum porterii-osha, Matricaria recutita, Melissa officinalis, Salix alba, Thymus vulgaris, Uncaria tomentosa, Usnea barbata or Vaccinium myrtillus;
- b) an adhesive layer comprising:
- 50% or more by weight polymer(s) comprising an adhesion-promoting amount of carbamer and one or more soluble polymers,
- wherein the adhesive layer becomes adhesive as it is placed against a mucosal surface and begins to absorb moisture therefrom, and the adhesion of the adhesive layer is less aggressive than would pertain for an adhesive layer consisting of polymers including 40% or more by weight of Carbopol 940 and said antiinflammatory amount of said extracts,
- and wherein the extracts are substantially comprised in the adhesive layer;
- and
- c) a less adhesive protective layer, wherein the protective layer has components selected to be, on the whole, relatively less dissolvable than those of adhesive layer;
- wherein the film, when placed on an oral mucosal surface, dissolves away completely after 15 minutes or more and dissolution is such that such film can be applied to an oral mucosal lesion two or more times per day without film removal from the lesion,
- wherein the film has only the two layers,
- and wherein the film, if periodically applied to an aphthous or trauma-related ulcer, is effective in ameliorating such ulcer.
7 more elements
Dependencies are inferred from the claim text.