Methods of organ regeneration using Hox11-expressing pluripotent cells
AssigneeThe General Hospital Corporation
InventorDenise L. Faustman
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Abstract
The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has injured or damaged cells of the predetermined type or is deficient in cells of the predetermined type.
Claims25
A method for increasing or maintaining the number of functional cells of a predetermined type in an organ or tissue of a mammal, wherein said organ or tissue is injured, damaged, or deficient in said functional cells and wherein said organ or tissue is, or is part of, pancreas, spleen, liver, kidney, bone, blood, vascular tissue, brain, spinal cord, nervous system tissue, heart, bile duct, skin, bladder, eye, stomach, intestines, muscle, ligament, cartilage, esophagus, gallbladder, lung, ovaries, prostate, testes, thymus, ureter, urethra, uterus, or fat, said method comprising administering to said mammal a composition enriched in pluripotent cells from an adult mammal, wherein said pluripotent cells endogenously express the Hox ll gene.
Dependencies are inferred from the claim text.