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US 8,017,648 B2Granted
Methods of use of cyclopamine analogs
AssigneeInfinity Pharmaceuticals, Inc.
InventorsAlfredo C. Castro, Michael J. Grogan, Karen J. McGovern, Martin Tremblay
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Abstract
The invention provides methods for treating various conditions using derivatives of cyclopamine having the following formula:
Claims21
A method for antagonizing the hedgehog pathway in a mammal comprising administering to the mammal a compound of the formula:
- or a pharmaceutically acceptable salt thereof.
A method for treating cancer in a mammal comprising administering to the mammal a compound of formula:
- or a pharmaceutically acceptable salt thereof;
- wherein said cancer is selected from the group consisting of basal cell carcinoma, glioma, breast cancer, chondrosarcoma, colon cancer, esophageal cancer, gastric cancer, gastrointestinal stromal tumor, hepatocellular cancer, lung cancer, medulloblastoma, melanoma, neuroectodermal tumors, osteogenic sarcoma, ovarian cancer, pancreatic cancer, prostate cancer, and testicular cancer.
Dependencies are inferred from the claim text.