Tryptophanyl-tRNA synthetase-derived polypeptides useful for the regulation of angiogenesis
AssigneeThe Scripps Research Institute
InventorsPaul Schimmel, Keisuke Wakasugi, Martin Friedlander
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Abstract
The invention provides a method for inhibiting ocular neovascularization in a patient. The method comprises administering to a patient an ocular neovascularization inhibiting amount of a water-soluble polypeptide selected from the group consisting of SEQ ID NO: 12, SEQ ID NO: 7, and an ocular neovascularization inhibiting fragment thereof, which includes at least one of amino acid residue signature sequences HVGH (SEQ ID NO:10) and KMSAS (SEQ ID NO:11). A method for assaying the angiogenesis inhibiting activity of a composition is also provided.
Claims18
A composition comprising an isolated nucleic acid encoding a tryptophanyl-t tRNA synthetase consisting of a nucleotide sequence encoding a water-soluble polypeptide fragment of human tryptophanyl-tRNA synthetase, the region of the nucleotide sequence encoding said fragment consisting of a nucleotide sequence that is at least 95 percent identical to the sequence of a polynucleotide selected from the group consisting of a polynucleotide of SEQ ID NO:
- 6, a polynucleotide that encodes the polypeptide consisting of SEQ ID NO:
- 7 and a polynucleotide that encodes a polypeptide consisting of SEQ ID NO:
- 12, in combination with a pharmaceutically acceptable excipient.
Dependencies are inferred from the claim text.