Hox11+, CD45− cells and methods of organ regeneration using the same
AssigneeThe General Hospital Corporation
InventorDenise Faustman
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Abstract
The invention features methods for increasing or maintaining the number of functional cells of a predetermined type in a mammal (e.g., a human patient), for example, the insulin producing cells of the pancreas, liver cells, spleen cells, or bone cells, that has injured or damaged cells of the predetermined type or is deficient in cells of the predetermined type.
Claims7
An isolated mammalian cell, wherein said cell endogenously expresses Hox11 (Hox11 (+)) and lacks expression of CD45 (CD45(−)) wherein said cell can differentiate into two or more different cell types, and wherein said cell is obtained from spleen or mobilized into peripheral blood from the spleen.
Dependencies are inferred from the claim text.