Method of supporting a diagnosis of a risk of cancer recurrence, and a device of supporting a diagnosis of a risk of cancer recurrence

A method supporting a diagnosis of a risk of cancer recurrence, comprising:

• measuring in a malignant tumor sample collected from a patient an expression level of a first cyclin dependent kinase (CDK), an activity value of the first CDK, an expression level of a second CDK and an activity value of the second CDK from a malignant tumor collected from a cancer patient to be examined;
• calculating a first CDK specific activity which is calculated by using a ratio of the expression level and the activity value of the first CDK, and a second CDK specific activity which is calculated by using a ratio of the expression level and the activity value of the second CDK;
• and
• displaying a recurrence risk judgment graph which comprises at least two parameters of a first CDK specific activity and a second CDK specific activity, and is divided into zones different in a recurrence risk score calculated by a fourth formula comprising
• recurrence risk score=F(X)×G(Y),
• wherein the cancer patients to be examined are plotted based on the first CDK specific activity and the second CDK specific activity on the judgment graph,
• wherein X represents a first CDK specific activity;
• wherein Y represents a specific activity ratio which is a ratio of the first CDK specific activity to the second CDK specific activity,
• wherein F(X) is a function of a correlation of X with a cancer recurrence rate, and
• wherein G(Y) is a function of a correlation of Y with the cancer recurrence rate.

A device supporting a diagnosis of a risk of cancer recurrence, comprising:

• measurement section measuring a malignant tumor collected from a cancer patient to be examined to acquire an expression level of a first cyclin dependent kinase (CDK), an activity value of the first CDK, an expression level of a second CDK and an activity value of the second CDK;
• and
• a controller including a memory under control of a processor, the memory storing instructions enabling the processor to carry out operations which comprise calculating a recurrence risk score by a fifth formula comprising
• recurrence risk score=F(X)×G(Y),
• wherein X represents a first CDK specific activity which a ratio of the activity value of the first CDK to the expression level of the first CDK;
• wherein Y represents a specific activity ratio which is a ratio of a second CDK specific activity to the first CDK specific activity,
• wherein the second CDK specific activity is a ratio of the expression level of the second CDK to the activity value of the second CDK,
• wherein F(X) is a function of a correlation of X with a cancer recurrence rate, and
• wherein G(Y) is a function of a correlation of Y with the cancer recurrence rate.

A device supporting a diagnosis of a risk of cancer recurrence, comprising:

• measurement section measuring a malignant tumor collected from a cancer patient to be examined to acquire an expression level of a first cyclin dependent kinase (CDK), an activity value of the first CDK, an expression level of a second CDK and an activity value of the second CDK;
• and
• a controller system including a display and a memory under control of a processor, the memory storing instructions enabling the processor to carry out operations, comprising:
• calculating a first CDK specific activity which is calculated by using a ratio of the expression level and the activity value of the first CDK acquired by the measurement section, and a second CDK specific activity which is calculated by using a ratio of the expression level and the activity value of the second CDK acquired by the measurement section;
• and
• displaying a recurrence risk judgment graph which comprises at least two parameters of a first CDK specific activity and a second CDK specific activity, and is divided into zones different in a recurrence risk score calculated by an eighth formula comprising
• recurrence risk score=F(X)×G(Y),
• wherein the cancer patients to be examined are plotted based on the first CDK specific activity and the second CDK specific activity on the judgment graph,
• wherein X represents a first CDK specific activity;
• wherein Y represents a specific activity ratio which is a ratio of the first CDK specific activity to the second CDK specific activity,
• wherein F(X) is a function of a correlation of X with a cancer recurrence rate, and
• wherein G(Y) is a function of a correlation of Y with the cancer recurrence rate.