US 8,014,957 B2 · Genes associated with progression and response in chronic myeloid leukemia and uses thereof

Abstract

The invention provides molecular markers that are associated with the progression of chronic myeloid leukemia (CML), and methods and computer systems for monitoring the progression of CML in a patient based on measurements of these molecular markers. The present invention also provides CML target genes, and methods and compositions for treating CML patients by modulating the expression or activity of these CML target genes and/or their encoded proteins. The invention also provides genes that are associated with resistance to imatinib mesylate (Gleevec™) treatment in CML patients, and methods and compositions for determining the responsiveness of a CML patient to imatinib mesylate treatment based on measurements of these genes and/or their encoded proteins. The invention also provides methods and compositions for enhancing the effect of Gleevec™ by modulating the expression or activity of these genes and/or their encoded proteins.

Claims16

Dependent claims

A computer-implemented method for determining progression of chronic myeloid leukemia (CML) in a CML patient, comprising:

(a) classifying, on a computer, a marker profile comprising measurements of a plurality of gene products in a cell sample taken from said patient as a chronic phase (CP-CML) profile or as an advanced phase (ADV-CML) profile, wherein said gene products are respectively products of at least 5 of the genes listed in Table 1a;
(b) determining said patient as in a chronic phase if said marker profile is classified as a CP-CML profile, or determining said patient as in an advanced phase if said marker profile is classified as an ADV-CML profile;
and
(c) outputting to a user, a user interface device, a monitor, a computer readable storage medium, a local computer, or a computer that is part of a network;
or displaying;
the determination resulting from step (b).

3 more elements

Dependencies are inferred from the claim text.

Genes associated with progression and response in chronic myeloid leukemia and uses thereof

Life of this patent

Genes associated with progression and response in chronic myeloid leukemia and uses thereof

Life of this patent

Abstract

Claims16