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AssigneeThe Regents of the University of California
InventorsSteven E. Brenner, Richard E. Green, R. Tyler Hillman
Estimating the term…
Computational methods for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD) comprise: (a) identifying a dataset of target putative protein isoform sequences for characterization; (b) identifying from an mRNA dataset corresponding mRNA sequences representing transcripts encoding the protein isoforms; (c) determining corresponding gene intron-exon structures by mapping the mRNA sequences to corresponding genomic sequences; and (d) determining if the transcripts are apparent targets of NMD. Methods for regulating the expression of a gene encoding a protein isoform characterized as an apparent target of NMD comprise biasing expression of the isoform by modulating transcript splicing or modulating NMD activity.
A method for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD), the method comprising the following steps, each of which is performed with a suitably programmed computer:
A method for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD), the method comprising the following steps, each of which is performed with a suitably programmed computer:
A computer program product, comprising a computer usable medium having a computer readable program code embodied therein, said computer readable program code adapted to be executed to implement a method for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD) and for generating and outputting a list of said isoforms, the method comprising the following steps:
A computer program product, comprising a computer usable medium having a computer readable program code embodied therein, said computer readable program code adapted to be executed to implement a method for systematically characterizing putative protein isoforms as apparent targets of nonsense-mediated decay (NMD) and for generating and outputting a list of said isoforms, the method comprising the following steps:
Dependencies are inferred from the claim text.