Feedback control device for transcutaneous drug delivery and uses therefor
AssigneeRocky Mountain Biosystems, Inc.
InventorsKevin S. Marchitto, Stephen T. Flock
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Abstract
Provided herein is a device for altering a biological membrane in an individual comprising a means for delivering energy to the surface of the biological membrane, a means for monitoring a physiological state of the biological membrane during delivery of said energy, a means for modulating delivery of the energy to the biological membrane where the modulating is in response to a change in the monitored physiological state. Also provided is a device to control the permeation of substance across a biological membrane and methods for use of these devices.
Claims17
A device for altering a biological membrane, wherein the biological membrane is the stratum corneum, in an individual comprising:
- an energy delivery system;
- one or more first active electrodes operably connected to the energy delivery system and in electrical contact with a treatment site on the biological membrane;
- and
- a second return electrode distal to the first electrode(s) and in electrical contact with the biological membrane;
- a controller configured to monitor a change in current flow between the first electrode(s) and the second electrode, said change in current flow corresponding to a change in a physiological state of the biological membrane;
- and
- a microprocessor operably connected to the controller and to the energy delivery system and configured to modulate energy delivery from the energy delivery system to at least one first electrode in response to the change in current flow between the first electrode(s) and the second electrode.
Dependencies are inferred from the claim text.