NMR clinical analyzers and related methods, systems, modules and computer program products for clinical evaluation of biosamples

A method of operating a clinical NMR in vitro diagnostic analyzer, comprising:

• electronically monitoring data associated with a plurality of selected parameters of a clinical NMR analyzer;
• electronically determining whether the selected parameters are within desired operational ranges based on the monitored data,
• automatically adjusting operational parameters of selected components of the clinical NMR analyzer based on data obtained by the electronically determining step;
• obtaining NMR signal spectra of a biosample;
• electronically generating at least one clinical measurement of the biosample based on the obtained NMR spectra;
• and
• before the obtaining step, serially aspirating biosamples from respective sample containers into an enclosed flow path and automatically serially detecting patient identification data for each respective patient biosample at a point of aspiration into the enclosed flow path to thereby inhibit incorrect patient biosample correlation.

A method of operating a clinical NMR in vitro analyzer in a patient biosample test laboratory without an onsite dedicated NMR support technician, the clinical analyzer comprising an NMR spectrometer with a magnet having a bore, the method comprising the steps of:

• automatically introducing in vitro biosamples into a top-loaded flow probe held in the magnet bore of the NMR spectrometer;
• electronically detecting data associated with selected operating parameters of the clinical NMR analyzer during normal operation;
• electronically verifying that selected conditions of the clinical NMR analyzer are within target operating ranges on the basis of the detected data;
• executing an automated electronic self-diagnostic quality control and/or calibration test during operation using a calibration standard introduced to the flow probe;
• and
• electronically obtaining NMR spectra for at least 400 biosamples per twenty-four hours and generating quantitative measurements based on the obtained NMR spectra.