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US 8,013,187 B2Granted
2-cyclopenten-1-one oxime derivatives inhibiting production of TNF-α
AssigneeAmorepacific Corporation
InventorsYeonjoon Kim, Sun-Young Kim, Jung Sun Hwang, Kyoung Min Lim, Miyoung Park, Hyun Ju Koh, Sa-Yong Hong, Song Seok Shin, Jin Kyu Choi, Joo-Hyun Moh, Shin Chung, Byoung Young Woo, Sung Il Kim
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Abstract
2-cyclopenten-1-one oxime derivatives represented by Formula (I), or pharmaceutically acceptable salts thereof inhibit the production of TNF-α or PDE4, and therefore show therapeutic effect in inflammatory or immunological disorders mediated through TNF-α or PDE4.
Claims10
A compound represented by Formula I provided below, or a pharmaceutically acceptable salt thereof:
- wherein,
- R1 represents a linear or branched C1-C10 alkyl group, or a C3-C7 cycloalkyl group;
- and
- R2 represents an aromatic group selected from the group consisting of phenyl, pyridyl, naphthyl, indolyl, thienyl, benzo[b]thienyl, dibenzofuranyl, and thianthrenyl, wherein said phenyl is unsubstituted or substituted by:
- one to three substituent(s) selected from the group consisting of a linear C1-C9 alkyl group, phenyl, halo, nitro, alkoxy, cyano and hydroxy, or
- one substituent selected from the group consisting of alkenyl, haloalkyl, amino, alkylamino, alkylaminoalkyl, methylenedioxy, haloalkoxy, benzyloxy, alkylthio, alkylsulfonyl, alkylsulfinyl, alkoxycarbonyl, alkoxyalkyl, hydroxyalkyl, carbamoyl, N-hydroxy-iminoalkyl and N-(N-hydroxy-iminoalkyl).
3 more elements
Dependencies are inferred from the claim text.