Substituted pyrrolo[1,2-d][1,4]-diazonines and treatment of brain damage

Abstract

Embodiments of this invention provide novel peptidomimetics that contain a macrocycle, an embodiment of which is 2S,9′S,12′S)-2-{[(1′,4′-Diaza-2′-oxobicyclo[7.3.0]dodecyl)-12′-carbonyl]amino}-1,5-pentanedioic acid trifluoroacetate. Such compounds are neuroprotective and have utility as therapeutic agents for treatment of diseases, injuries and other conditions characterized by neuronal degeneration and/or neuronal cell death caused by in embodiments, toxicity or hypoxia. Compounds are also useful for manufacture of medicaments useful for treatment of such conditions.

Dependencies are inferred from the claim text.