Method for preparing substituted pyrimidines
AssigneeE. I. Du Pont de Nemours and Company
InventorGary David Annis
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Abstract
Disclosed a method for preparing a compound of Formula 1, wherein R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; comprising contacting a compound of Formula 2 with a persulfate oxidant in the presence of a strong sulfur- or phosphorus-containing mineral acid and an oxidation resistant solvent. Also disclosed are methods for preparing the compound of Formula 2 from a compound of Formula 5 as well as compounds of Formula 6 and salts thereof, wherein R is NH2, Cl or OH; X is H or Cl; R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl; and R2 is C1-C14 alkyl; provided that when R is NH2 or Cl, then X is Cl; which are useful a process intermediates.
Claims16
A method for preparing a compound of Formula 1,
- wherein R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl;
- and R2 is C1-C14 alkyl;
- comprising contacting a compound of Formula 2
- with a persulfate oxidant in the presence of a strong sulfur- or phosphorus-containing mineral acid.
A compound of Formula 6, or a salt thereof,
- wherein R is NH2, Cl or OH;
- X is Cl;
- R1 is cyclopropyl, 4-chlorophenyl or 4-bromophenyl;
- and R2 is C1-C14 alkyl.
Dependencies are inferred from the claim text.