Substituted pyrimidine kinase inhibitors

A compound of Formula (I):

• or a salt, stereoisomer, or tautomer thereof, wherein
• L is selected from the group consisting of O and O—CH2, wherein the O atom portion of O—CH2 is attached to the pyrimidine ring of formula (I);
• Ar is selected from the group consisting of aryl, heteroaryl, benzofused-heterocyclyl and benzofused-C3-12cycloalkyl, wherein the benzene ring portion of the benzofused ring system is attached to the L group of formula (I);
• RA is selected from the group consisting of CH═N—O—R1 and cyano;
• R1 is selected from the group consisting of hydrogen, C1-8alkyl, C2-8alkenyl, C2-8alkynyl, C1-8alkoxy-C1-8alkyl, hydroxy-C1-8alkyl, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, C1-8alkoxy-C1-8alkyl-amino-C1-8alkyl, C1-8alkyl-sulfonyl-C1-8alkyl, C1-8alkyl-sulfonyl-oxy-C1-8alkyl, C3-12cycloalkyl, C3-12cycloalkyl-C1-8alkyl, aryl, aryl-C1-8alkyl, aryl-oxy-C1-8alkyl, heterocyclyl, heterocyclyl-C1-8alkyl, heterocyclyl-carbonyl-C1-8alkyl, heteroaryl and heteroaryl-C1-8alkyl,
• wherein aryl and aryl-C1-8alkyl are each optionally substituted on aryl with one, two, three, four or five substituents each selected from the group consisting of hydroxy, C1-8alkyl, C1-8alkoxy, amino, C1-8alkyl-amino and C1-8alkoxy-carbonyl, and
• wherein heterocyclyl, heterocyclyl-C1-8alkyl and heterocyclyl-carbonyl-C1-8alkyl are each optionally substituted on heterocyclyl with one, two, three or four substituents each selected from the group consisting of hydroxy, C1-8alkyl, C1-8alkoxy, amino, C1-8alkyl-amino, C1-8alkyl-carbonyl, C1-8alkoxy-carbonyl, C1-8alkyl-sulfonyl and C1-8alkyl-sulfonyl-C1-8alkyl;
• R2 is selected from the group consisting of hydrogen, C1-8alkyl and C1-8alkoxy;
• and
• R3, R4, R5, R6 and R7 is each selected from the group consisting of hydrogen, cyano, halogen, hydroxy, carboxy, C1-8alkyl, C1-8alkyl-carbonyl, C1-8alkyl-carbonyl-C1-8alkyl, C1-8alkyl-carbonyl-amino, C1-8alkyl-carbonyl-amino-C1-8alkyl, C1-8alkoxy, C1-8alkoxy-carbonyl, C1-8alkoxy-carbonyl-amino, C1-8alkoxy-C1-8alkyl, C1-8alkoxy-C1-8alkyl-carbonyl, C1-8alkoxy-C1-8alkyl-carbonyl-amino, hydroxy-C1-8alkyl, hydroxy-C1-8alkyl-amino-carbonyl, hydroxy-C1-8alkyl-amino-carbonyl-amino, halo-C1-8alkyl, hydroxy-C1-8alkoxy, halo-C1-8alkoxy, C2-8alkenyl, C2-8alkynyl, C1-8alkoxy-imino-C1-8alkyl, C1-8alkoxy-imino-C2-8alkenyl, amino, C1-8alkyl-amino, amino-carbonyl, C1-8alkyl-amino-carbonyl, C2-8alkenyl-amino-carbonyl, C2-8alkynyl-amino-carbonyl, amino-carbonyl-C1-8alkyl C1-8alkyl-amino-carbonyl-C1-8alkyl, C2-8alkenyl-amino-carbonyl-C1-8alkyl, C2-8alkynyl-amino-carbonyl-C1-8alkyl, C1-8alkyl-amino-carbonyl-amino, C2-8alkenyl-amino-carbonyl-amino, C2-8alkynyl-amino-carbonyl-amino, C1-8alkyl-amino-carbonyl-oxy, C2-8alkenyl-amino-carbonyl-oxy, C2-8alkynyl-amino-carbonyl-oxy, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl, amino-C1-8alkyl-amino-carbonyl, C1-8alkyl-amino-C1-8alkyl-amino-carbonyl, amino-C1-8alkyl-amino-carbonyl-amino, C1-8alkyl-amino-C1-8alkyl-amino-carbonyl-amino, C3-12cycloalkyl, C3-12cycloalkyl-C1-8alkyl, C3-12cycloalkyl-C1-8alkoxy, C3-12cycloalkyl-amino-carbonyl, C3-12cycloalkyl-amino-carbonyl-amino, C3-12cycloalkyl-C1-8alkyl-amino-carbonyl, C3-12cycloalkyl-C1-8alkyl-amino-carbonyl-amino, C3-12cycloalkyl-amino-carbonyl-C1-8alkyl, aryl, aryl-oxy, aryl-C1-8alkyl, aryl-C1-8alkoxy, aryl-carbonyl, aryl-amino, aryl-amino-carbonyl, aryl-amino-carbonyl-amino, aryl-C1-8alkyl-amino-carbonyl, aryl-C1-8alkyl-amino-carbonyl-amino, aryl-amino-carbonyl-C1-8alkyl, aryl-amino-carbonyl-oxy, heteroaryl, heteroaryl-oxy, heteroaryl-C1-8alkoxy, heteroaryl-amino-carbonyl, heteroaryl-amino-carbonyl-amino, heteroaryl-C1-8alkyl-amino-carbonyl, heteroaryl-C1-8alkyl-amino-carbonyl-amino, heteroaryl-amino-carbonyl-C1-8alkyl, heterocyclyl, heterocyclyl-C1-8alkyl, heterocyclyl-C1-8alkyl-amino-carbonyl, heterocyclyl-C1-8alkyl-amino-carbonyl-amino and heterocyclyl-amino-carbonyl-C1-8alkyl,
• wherein aryl, aryl-oxy, aryl-C1-8alkyl, aryl-C1-8alkoxy, aryl-carbonyl, aryl-amino, aryl-amino-carbonyl-amino, aryl-C1-8alkyl-amino-carbonyl, aryl-C1-8alkyl-amino-carbonyl-amino, aryl-amino-carbonyl-C1-8alkyl, aryl-amino-carbonyl-oxy, heteroaryl and heteroaryl-amino-carbonyl-amino are each optionally substituted on aryl and heteroaryl with one, two, three, four or five substituents each selected from the group consisting of cyano, halogen, hydroxy, C1-8alkyl, C1-8alkoxy, amino, C1-8alkyl-amino, amino-C1-8alkyl, C1-8alkyl-amino-C1-8alkyl and C1-8alkoxy-carbonyl.