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US 8,013,151 B2Granted
Process for the preparation of galanthamine hydrobromide
AssigneeIndena S.p.A.
InventorsBruno Gabetta, Enrico Mercalli
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Abstract
A process for the purification of galanthamine (I) comprising precipitation of galanthamine hydrobromide from a mixture of alkaloids obtained from a plant of the Amaryllidaceae family containing galanthamine, treatment of the hydrobromide with alkali, extraction and crystallization of galanthamine with a solvent of general formula (II), in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl. The resulting pure galanthamine can be conveniently used for the preparation of galanthamine hydrobromide.
Claims12
A process for the purification of galanthamine (I)
- comprising the following steps:
- a) addition of hydrobromic acid to a mixture of alkaloids containing galanthamine obtained from a plant of the Amaryllidaceae family;
- b) recovery of the precipitate;
- c) dissolution of the precipitate in a basic aqueous solution;
- d) extraction with a solvent of formula (II)
- in which R1 is hydrogen or methyl and R2 is selected from n-butyl, isobutyl, sec-butyl and t-butyl;
- e) concentration of the organic phase;
- f) optional recovery of the precipitated galanthamine (I).
5 more elements
Dependencies are inferred from the claim text.