Genetic modification of targeted regions of the cardiac conduction system
AssigneeMedtronic, Inc.
InventorsVinod Sharma, Walter H. Olson
Life of this patent
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Abstract
Disclosed are methods and systems for preventing or treating cardiac dysfunction, particularly cardiac pacing dysfunction by genetic modification of the conduction system of the heart. In one embodiment, the invention provides a method of genetically modifying the cells by delivering to the cells one or more coding sequence in a genetic construct capable of modifying the expression of ion channels of the cells.
Claims9
A bio-pacemaker composition comprising at least two coding sequences selected from the group consisting of:
- (i) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, at least one T-type Ca2+ channel subunit, including α1H;
- (ii) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, one or more molecules that increase If, including HCN1, HCN2, HCN3, or HCN4;
- and (iii) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fibers, one or more molecules that increases IK, including erg1, MiRP, MinK, or KvLQT1.
A bio-pacemaker composition comprising:
- isolated coding sequences that encode, in myocardial cells of cardiac Purkinje fibers, His bundle and/or upper bundle branches:
- a T-type Ca2+ channel subunit, including α1H,
- one or more molecules that increase If;
- including HCN1, HCN2, HCN3, or HCN4, and
- one or more molecules that increase IK, including erg1, MiRP, MinK, or KvLQT1.
A bio-pacemaker for myocardial cells of the cardiac Purkinje fibers, the bio-pacemaker made by the process of delivering to the myocardial cells of the cardiac Purkinje fibers a composition comprising at least two coding sequences selected from the group consisting of:
- (i) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fiber, at least one T-type Ca2+ channel subunit, including α1H;
- (ii) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fiber, one or more molecules that increase If, including HCN1, HCN2, HCN3, or HCN4;
- and (iii) an isolated coding sequence that encodes, in myocardial cells of cardiac Purkinje fiber, one or more molecules that increases IK, including erg1, MiRP, MinK, or KvLQT1.
Dependencies are inferred from the claim text.