Antibodies and related molecules that bind to PSCA proteins

A method of inhibiting tumor cell growth, comprising:

• administering to a patient in need thereof a monoclonal antibody or antigen binding fragment thereof in conjunction with administration of a chemotherapeutic agent, radiation or both, wherein the monoclonal antibody or antigen binding fragment thereof comprises an antigen binding site that binds specifically to a PSCA protein comprising the amino acid sequence of SEQ ID NO:2, and wherein the monoclonal antibody or antigen binding fragment thereof comprises the amino acid sequence of the VH region of SEQ ID NO:
• 47 and the VL region of SEQ ID NO:
• 51.

A method of treating a cancer that expresses a PSCA protein, comprising:

• administering to a patient in need thereof a monoclonal antibody or antigen binding fragment thereof in conjunction with administration of a chemotherapeutic agent, radiation or both, wherein the monoclonal antibody or antigen binding fragment thereof comprises an antigen binding site that binds specifically to a PSCA protein on a cancer cell comprising the amino acid sequence of SEQ ID NO:2, and wherein the monoclonal antibody or antigen binding fragment thereof comprises the amino acid sequence of the VH region of SEQ ID NO:
• 47 and the VL region of SEQ ID NO:
• 51.